Microglia are increasingly implicated in brain pathology, particularly neurodegenerative
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …

The gene IGF2, which encodes a fetal insulin-like growth factor, is imprinted, so only one of
two parental copies of the gene is expressed. The altered expression of IGF2 has been …

The Insulin-like growth factor 2 (Igf2) and H19 genes are reciprocally imprinted and closely
linked. Igf2 encodes a fetal growth-factor and is predominantly expressed from the paternal …

While roles in adhesion and morphogenesis have been documented for classical cadherins,
the nonclassical cadherins are much less well understood. Here we have examined the …

To study the function of astrocytes in the adult brain, we have targeted the expression of E.
coli nitroreductase (NTR) to the astrocytes of transgenic mice under the control of the GFAP …

Expression and DNA methylation of the transgene locus TKZ751 are controlled by genotype-specific
modifier genes. The DBAl2 and 129 genetic backgrounds enhanced expression, …

The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …

We have created a transgenic mouse with a hypomorphic allele of the vesicular monoamine
transporter 2 (Vmat2) gene by gene targeting. These mice (KA1) have profound changes in …

During development, spinal cord oligodendrocyte precursors (OPCs) originate from the
ventral, but not dorsal, neuroepithelium. Sonic hedgehog (SHH) has crucial effects on …

A detailed analysis of the developmental potential of parthenogenetic embryonic stem cells (PGES)
was made in vivo and in vitro, and a comparison was made with the development of …