Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …

Histone modifications are important markers of function and chromatin state, yet the DNA
sequence elements that direct them to specific genomic locations are poorly understood. Here, …

Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to …

Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However,
the identity of transitional states and the mechanisms that drive their trajectories remain …

Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels. …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel coronavirus 2019
(COVID-19) global pandemic has led to millions of cases and hundreds of thousands of …

Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve
treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current …

The advent of induced pluripotent stem cells (iPSCs) revolutionized human genetics by
allowing us to generate pluripotent cells from easily accessible somatic tissues. This technology …