Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons

…, BJ MacLennan, R Xu, YY Hou, TK Lavin, NE Lea… - Nature …, 2018 - nature.com
Recombinant rabies viral vectors have proven useful for applications including retrograde
targeting of projection neurons and monosynaptic tracing, but their cytotoxicity has limited their …

Targeting thalamic circuits rescues motor and mood deficits in PD mice

…, Y Zhu, Y Chen, T Aida, Y Hou, C Shen, NE Lea… - Nature, 2022 - nature.com
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with
Parkinson’s disease (PD), patients also experience motor learning impairments and non-motor …

[PDF][PDF] Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

…, Y Zhang, T Aida, S Choi, Q Chen, Y Hou, NE Lea… - Neuron, 2021 - cell.com
Neuropsychiatric disorders are often accompanied by cognitive impairments/intellectual
disability (ID). It is not clear whether there are converging mechanisms underlying these …

[HTML][HTML] Monosynaptic tracing success depends critically on helper virus concentrations

TK Lavin, L Jin, NE Lea, IR Wickersham - Frontiers in Synaptic …, 2020 - frontiersin.org
Monosynaptically-restricted transsynaptic tracing using deletion-mutant rabies virus (RV)
has become a widely used technique in neuroscience, allowing identification, imaging, and …

In Vivo Behavior of the Tandem Glycine Riboswitch in Bacillus subtilis

AM Babina, NE Lea, MM Meyer - MBio, 2017 - Am Soc Microbiol
In many bacterial species, the glycine riboswitch is composed of two homologous ligand-binding
domains (aptamers) that each bind glycine and act together to regulate the expression …

[PDF][PDF] Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency

L Jin, HA Sullivan, M Zhu, NE Lea, TK Lavin, X Fu… - Cell Reports …, 2023 - cell.com
Rabies viral vectors have become important components of the systems neuroscience toolkit,
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …

“Self-inactivating” rabies viruses are susceptible to loss of their intended attenuating modification

…, M Zhu, TK Lavin, YY Hou, NE Lea… - Proceedings of the …, 2023 - National Acad Sciences
Monosynaptic tracing using rabies virus is an important technique in neuroscience, allowing
brain-wide labeling of neurons directly presynaptic to a targeted neuronal population. A …

“Self-inactivating” rabies viruses are just first-generation, ΔG rabies viruses

…, L Jin, TK Lavin, HA Sullivan, YY Hou, NE Lea… - biorxiv, 2019 - biorxiv.org
A recent article in Cell reported a new form of modified rabies virus that was apparently capable
of labeling neurons “without adverse effects on neuronal physiology and circuit function”…

[HTML][HTML] Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses

…, M Zhu, TK Lavin, M Matsuyama, X Fu, NE Lea… - Nature …, 2024 - nature.com
Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural
circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present …

Single-deletion-mutant, third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency

L Jin, HA Sullivan, M Zhu, NE Lea, TK Lavin, X Fu… - BioRxiv, 2022 - biorxiv.org
Rabies viral vectors have become important components of the systems neuroscience toolkit,
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …