Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons
…, BJ MacLennan, R Xu, YY Hou, TK Lavin, NE Lea… - Nature …, 2018 - nature.com
Recombinant rabies viral vectors have proven useful for applications including retrograde
targeting of projection neurons and monosynaptic tracing, but their cytotoxicity has limited their …
targeting of projection neurons and monosynaptic tracing, but their cytotoxicity has limited their …
Targeting thalamic circuits rescues motor and mood deficits in PD mice
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with
Parkinson’s disease (PD), patients also experience motor learning impairments and non-motor …
Parkinson’s disease (PD), patients also experience motor learning impairments and non-motor …
[PDF][PDF] Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models
Neuropsychiatric disorders are often accompanied by cognitive impairments/intellectual
disability (ID). It is not clear whether there are converging mechanisms underlying these …
disability (ID). It is not clear whether there are converging mechanisms underlying these …
[HTML][HTML] Monosynaptic tracing success depends critically on helper virus concentrations
TK Lavin, L Jin, NE Lea, IR Wickersham - Frontiers in Synaptic …, 2020 - frontiersin.org
Monosynaptically-restricted transsynaptic tracing using deletion-mutant rabies virus (RV)
has become a widely used technique in neuroscience, allowing identification, imaging, and …
has become a widely used technique in neuroscience, allowing identification, imaging, and …
In Vivo Behavior of the Tandem Glycine Riboswitch in Bacillus subtilis
In many bacterial species, the glycine riboswitch is composed of two homologous ligand-binding
domains (aptamers) that each bind glycine and act together to regulate the expression …
domains (aptamers) that each bind glycine and act together to regulate the expression …
[PDF][PDF] Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency
L Jin, HA Sullivan, M Zhu, NE Lea, TK Lavin, X Fu… - Cell Reports …, 2023 - cell.com
Rabies viral vectors have become important components of the systems neuroscience toolkit,
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …
“Self-inactivating” rabies viruses are susceptible to loss of their intended attenuating modification
…, M Zhu, TK Lavin, YY Hou, NE Lea… - Proceedings of the …, 2023 - National Acad Sciences
Monosynaptic tracing using rabies virus is an important technique in neuroscience, allowing
brain-wide labeling of neurons directly presynaptic to a targeted neuronal population. A …
brain-wide labeling of neurons directly presynaptic to a targeted neuronal population. A …
“Self-inactivating” rabies viruses are just first-generation, ΔG rabies viruses
…, L Jin, TK Lavin, HA Sullivan, YY Hou, NE Lea… - biorxiv, 2019 - biorxiv.org
A recent article in Cell reported a new form of modified rabies virus that was apparently capable
of labeling neurons “without adverse effects on neuronal physiology and circuit function”…
of labeling neurons “without adverse effects on neuronal physiology and circuit function”…
[HTML][HTML] Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses
…, M Zhu, TK Lavin, M Matsuyama, X Fu, NE Lea… - Nature …, 2024 - nature.com
Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural
circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present …
circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present …
Single-deletion-mutant, third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency
L Jin, HA Sullivan, M Zhu, NE Lea, TK Lavin, X Fu… - BioRxiv, 2022 - biorxiv.org
Rabies viral vectors have become important components of the systems neuroscience toolkit,
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …
allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of …