The heterogeneity of neurodegenerative diseases is a key confound to disease understanding
and treatment development, as study cohorts typically include multiple phenotypes on …

See Stankoff and Louapre (doi: 10.1093/brain/awy114 ) for a scientific commentary on this
article. Grey matter atrophy is present from the earliest stages of multiple sclerosis, but its …

We describe a computational method, plane of best fit (PBF), to quantify and characterize the
3D character of molecules. This method is rapid and amenable to analysis of large diverse …

Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive
decline in visual processing and atrophy of posterior brain regions. With the majority of cases …

Objective Individuals with Down syndrome ( DS ) have an extremely high genetic risk for
Alzheimer's disease ( AD ), however, the course of cognitive decline associated with …

Young onset Alzheimer’s disease (YOAD) is defined as symptom onset before the age of 65
years and is particularly associated with phenotypic heterogeneity. Atypical presentations, …

Objective Determining the sequence in which Huntington's disease biomarkers become
abnormal can provide important insights into the disease progression and a quantitative tool for …

We describe the development and application of an integrated, multiobjective optimization
workflow (MOARF) for directed medicinal chemistry design. This workflow couples a rule-…

Introduction This work aims to characterize the sequence in which cognitive deficits appear
in two dementia syndromes. Methods Event‐based modeling estimated fine‐grained …

Creativity research has a substantial history in psychology and related disciplines; one
component of this research tradition has specifically examined artistic creativity. Creativity …