User profiles for Nicholas J Maness
Nicholas ManessAssistant Professor of Microbiology, Tulane University Verified email at tulane.edu Cited by 3162 |
[HTML][HTML] Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
…, S Spencer, L Doyle-Meyers, RP Bohm, NJ Maness… - Nature, 2021 - nature.com
The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …
The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 …
Particular HLA alleles are associated with reduced human immunodeficiency virus replication.
It has been difficult, however, to characterize the immune correlates of viral control. An …
It has been difficult, however, to characterize the immune correlates of viral control. An …
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus …
The goal of an AIDS vaccine regimen designed to induce cellular immune responses
should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we …
should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we …
Exhaled aerosol increases with COVID-19 infection, age, and obesity
…, SZ Killeen, NJ Maness… - Proceedings of the …, 2021 - National Acad Sciences
COVID-19 transmits by droplets generated from surfaces of airway mucus during processes
of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 (…
of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 (…
[HTML][HTML] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Neurological manifestations are a significant complication of coronavirus disease (COVID-19),
but underlying mechanisms aren’t well understood. The development of animal models …
but underlying mechanisms aren’t well understood. The development of animal models …
[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine
…, KWM Green, BM Threeton, NJ Maness… - Science translational …, 2022 - science.org
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …
[HTML][HTML] Acute respiratory distress in aged, SARS-CoV-2–infected African green monkeys but not rhesus macaques
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly in …
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly in …
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here,
we found that 26% of nonhuman primates infected with Asian/American ZIKV in early …
we found that 26% of nonhuman primates infected with Asian/American ZIKV in early …
Nef secretion into extracellular vesicles or exosomes is conserved across human and simian immunodeficiency viruses
…, LM Costantini, TA Myers, B Schouest, NJ Maness… - MBio, 2018 - Am Soc Microbiol
Extracellular vesicles (EVs) or exosomes have been implicated in the pathophysiology of
infections and cancer. The negative regulatory factor (Nef) encoded by simian …
infections and cancer. The negative regulatory factor (Nef) encoded by simian …