User profiles for Nicholas J Maness

Nicholas Maness

Assistant Professor of Microbiology, Tulane University
Verified email at tulane.edu
Cited by 3162

[HTML][HTML] Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

…, S Spencer, L Doyle-Meyers, RP Bohm, NJ Maness… - Nature, 2021 - nature.com
The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …

The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 …

…, RC Johnson, GE May, NJ Maness… - Journal of …, 2006 - Am Soc Microbiol
Particular HLA alleles are associated with reduced human immunodeficiency virus replication.
It has been difficult, however, to characterize the immune correlates of viral control. An …

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus …

…, J Furlott, EJ Gonzalez, LJ Yant, NJ Maness… - Journal of …, 2006 - Am Soc Microbiol
The goal of an AIDS vaccine regimen designed to induce cellular immune responses
should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we …

Exhaled aerosol increases with COVID-19 infection, age, and obesity

…, SZ Killeen, NJ Maness… - Proceedings of the …, 2021 - National Acad Sciences
COVID-19 transmits by droplets generated from surfaces of airway mucus during processes
of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 (…

[HTML][HTML] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

…, K Chandler, G Lehmicke, GJ Bix, NJ Maness… - Nature …, 2022 - nature.com
Neurological manifestations are a significant complication of coronavirus disease (COVID-19),
but underlying mechanisms aren’t well understood. The development of animal models …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

…, R Veazey, G Piedimonte, NJ Maness… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …

Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine

…, KWM Green, BM Threeton, NJ Maness… - Science translational …, 2022 - science.org
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …

[HTML][HTML] Acute respiratory distress in aged, SARS-CoV-2–infected African green monkeys but not rhesus macaques

…, MB Barnes, M Pattison, PK Datta, NJ Maness… - The American journal of …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly in …

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

…, AT Panganiban, RS Veazey, X Wang, NJ Maness… - Nature medicine, 2018 - nature.com
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here,
we found that 26% of nonhuman primates infected with Asian/American ZIKV in early …

Nef secretion into extracellular vesicles or exosomes is conserved across human and simian immunodeficiency viruses

…, LM Costantini, TA Myers, B Schouest, NJ Maness… - MBio, 2018 - Am Soc Microbiol
Extracellular vesicles (EVs) or exosomes have been implicated in the pathophysiology of
infections and cancer. The negative regulatory factor (Nef) encoded by simian …