User profiles for Nicholas J Matheson
Nicholas MathesonUniversity of Cambridge Verified email at cam.ac.uk Cited by 6702 |
[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
…, G Dougan, KGC Smith, PJ Lehner, NJ Matheson… - elife, 2020 - elifesciences.org
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing
between countries, and existing programmes focus on screening symptomatic rather than …
between countries, and existing programmes focus on screening symptomatic rather than …
[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
…, VG Gorgoulis, SJA Buczacki, JH Lee, NJ Matheson… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …
[PDF][PDF] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
…, K Hunter, N Kingston, PJ Lehner, NJ Matheson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis…
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis…
[PDF][PDF] Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. …
available oxygen, is associated with proliferation across many organisms and conditions. …
NOTCH1 mediates a switch between two distinct secretomes during senescence
…, Y Ito, TW Kang, MP Weekes, NJ Matheson… - Nature cell …, 2016 - nature.com
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse
secretome, which provides complex functionality for senescent cells within the tissue …
secretome, which provides complex functionality for senescent cells within the tissue …
[HTML][HTML] Accelerated waning of the humoral response to COVID-19 vaccines in obesity
…, R Doffinger, MA Linterman, NJ Matheson… - Nature Medicine, 2023 - nature.com
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19)
infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; …
infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; …
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
IA Tchasovnikarova, RT Timms, NJ Matheson, K Wals… - Science, 2015 - science.org
Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation
have revealed the basis of much of our understanding of heterochromatin. We took an …
have revealed the basis of much of our understanding of heterochromatin. We took an …
Covid-19: should the public wear face masks?
B Javid, MP Weekes, NJ Matheson - Bmj, 2020 - bmj.com
When covid-19 became a global health emergency, there was a visible contrast between the
responses of citizens in east Asia and the rest of the world. In east Asia, wearing of masks …
responses of citizens in east Asia and the rest of the world. In east Asia, wearing of masks …
[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …