User profiles for Nicholas J Matheson

Nicholas Matheson

University of Cambridge
Verified email at cam.ac.uk
Cited by 6702

[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

…, A Sigal, F Sampaziotis, IG Goodfellow, NJ Matheson… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

…, G Dougan, KGC Smith, PJ Lehner, NJ Matheson… - elife, 2020 - elifesciences.org
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing
between countries, and existing programmes focus on screening symptomatic rather than …

[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

…, VG Gorgoulis, SJA Buczacki, JH Lee, NJ Matheson… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …

[PDF][PDF] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

…, K Hunter, N Kingston, PJ Lehner, NJ Matheson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis…

[PDF][PDF] Increased demand for NAD+ relative to ATP drives aerobic glycolysis

…, CA Lewis, CJ Thomas, S Spranger, NJ Matheson… - Molecular cell, 2021 - cell.com
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. …

NOTCH1 mediates a switch between two distinct secretomes during senescence

…, Y Ito, TW Kang, MP Weekes, NJ Matheson… - Nature cell …, 2016 - nature.com
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse
secretome, which provides complex functionality for senescent cells within the tissue …

[HTML][HTML] Accelerated waning of the humoral response to COVID-19 vaccines in obesity

…, R Doffinger, MA Linterman, NJ Matheson… - Nature Medicine, 2023 - nature.com
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19)
infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; …

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

IA Tchasovnikarova, RT Timms, NJ Matheson, K Wals… - Science, 2015 - science.org
Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation
have revealed the basis of much of our understanding of heterochromatin. We took an …

Covid-19: should the public wear face masks?

B Javid, MP Weekes, NJ Matheson - Bmj, 2020 - bmj.com
When covid-19 became a global health emergency, there was a visible contrast between the
responses of citizens in east Asia and the rest of the world. In east Asia, wearing of masks …

[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles

…, M Zeviani, C Frezza, A Brisson, NJ Matheson… - PLoS …, 2021 - journals.plos.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …