Opportunistic infection in previously healthy women: initial manifestations of a community-acquired cellular immunodeficiency

…, JA SENDER, RS SIEBKEN, P NICHOLAS… - Annals of Internal …, 1982 - acpjournals.org
Opportunistic infections and unusual tumors have been reported in an unprecedented
outbreak of community-acquired cellular immune deficiency among homosexual and drug-…

[HTML][HTML] Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity

…, JP Goering, AJ Olm-Shipman, LA Hipp, NJ Ernst… - Plos one, 2021 - journals.plos.org
Topiramate is an anti-epileptic drug that is commonly prescribed not just to prevent seizures
but also migraine headaches, with over 8 million prescriptions dispensed annually. …

Risk of mortality according to body mass index and body composition among postmenopausal women

…, BC Wertheim, JS Nicholas, KC Ernst… - American journal of …, 2015 - academic.oup.com
Obesity, often defined as a body mass index (BMI; weight (kg)/height (m) 2 ) of 30 or higher,
has been associated with mortality, but age-related body composition changes can be …

[HTML][HTML] Selective homogeneous assay for circulating endopeptidase fibroblast activation protein (FAP)

…, NM Kljavin, NJ Skelton, J Sonoda, JA Ernst - Scientific Reports, 2017 - nature.com
Fibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression
is often elevated in activated fibroblasts associated with tissue remodeling in various …

[HTML][HTML] Integrative analysis of 111 reference human epigenomes

A Kundaje, W Meuleman, J Ernst, M Bilenky, A Yen… - Nature, 2015 - nature.com
The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

[HTML][HTML] Design and testing of a humanized porcine donor for xenotransplantation

…, A Akkad, S Chhangawala, RB Colvin, RJ Ernst… - Nature, 2023 - nature.com
Recent human decedent model studies 1 , 2 and compassionate xenograft use 3 have explored
the promise of porcine organs for human transplantation. To proceed to human studies, …

[BOOK][B] Murray & Nadel's textbook of respiratory medicine e-book

VC Broaddus, JD Ernst, TE King Jr, SC Lazarus… - 2021 - books.google.com
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel’s
Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing …

Teratogenic Drug Topiramate Upregulates TGFβ1 and SOX9 Expression in Primary Palatal Mesenchyme Cells

…, JP Goering, AJ Olm-Shipman, LA Hipp, NJ Ernst… - bioRxiv, 2020 - biorxiv.org
Topiramate is a commonly prescribed anti-epileptic drug with over 8 million prescriptions
dispensed annually. Topiramate use during pregnancy has been linked to significantly …

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

DM DiCara, N Andersen, R Chan, JA Ernst, G Ayalon… - MAbs, 2018 - Taylor & Francis
Developability assessment of therapeutic antibody candidates assists drug discovery by
enabling early identification of undesirable instabilities. Rapid chemical stability screening of …

Assessment of treatment patterns associated with injectable disease-modifying therapy among relapsing–remitting multiple sclerosis patients

J Nicholas, JJ Ko, Y Park… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Background Availability of oral disease-modifying therapy (DMT) for relapsing–remitting
multiple sclerosis (RRMS) may affect injectable DMT (iDMT) treatment patterns. Objective The …