Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Background Clinical prognostic groupings for localised prostate cancers are imprecise, with
30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We …

As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

Here we present the first digital particle image velocimetry (DPIV)analysis of the flow field
around the wings of an insect (the tobacco hawkmoth Manduca sexta, tethered to a 6-…

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant
tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.…

Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated
morbidity and mortality in Africa since the beginning of the century 1 . The intense selection …

Most proteins destined for the extracellular space require disulfide bonds for folding and
stability. Disulfide bonds are introduced co- and post-translationally in endoplasmic reticulum (…

Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan
Africa. However, insecticide resistance is entrenched in malaria vector populations, and …

Background We introduce BPG, a framework for generating publication-quality, highly-customizable
plots in the R statistical environment. Results This open-source package includes …