Secretory IgA (SIgA) serves as the first line of defense in protecting the intestinal epithelium
from enteric toxins and pathogenic microorganisms. Through a process known as immune …

Immune surveillance of mucosal surfaces requires the delivery of intact macromolecules and
microorganisms across epithelial barriers to organized mucosal lymphoid tissues. Transport…

Secretory IgA (SIgA) is the predominant class of antibody found in intestinal secretions.
Although SIgA's role in protecting the intestinal epithelium from the enteric pathogens and toxins …

M cells represent the primary route by which mucosal Ags are transported across the intestinal
epithelium and delivered to underlying gut-associated lymphoid tissues. In rodents and …

Immunoglobulin (Ig) A is by far the most abundantly produced Ig in the human body, yet its
physiological functions and pathological impact are incompletely understood. In part this is …

Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of disease
presentation, ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS). …

Secretory immunoglobulin A (SIgA) antibodies directed against the O antigen of lipopolysaccharide
(LPS) are the primary determinants of mucosal immunity to gram-negative enteric …

Type 1 reoviruses invade the intestinal mucosa of mice by adhering selectively to M cells in
the follicle-associated epithelium and then exploiting M cell transport activity. The purpose of …

Establishment of the gut microbiome during early life is a complex process with lasting
implications for an individual’s health. Several factors influence microbial assembly; however, …

Secretory IgA (SIgA), the predominant class of antibody in intestinal secretions, serves as
the first line of defense against enteric infections. SIgA has also been proposed to function in …