Although histone deacetylases (HDACs) are generally viewed as corepressors, we show
that HDAC1 serves as a coactivator for the glucocorticoid receptor (GR). Furthermore, a …

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genome
integrity. The first step in DSB repair by homologous recombination is the processing of the …

Despite a vast body of literature linking chromatin structure to regulation of gene expression,
the role of architectural proteins in higher order chromatin transitions required for …

The transition from transcription activation to repression is regulated at multiple levels by the
DNA sequence and DNA modification to its compaction through chromatin packaging. The …

Molecular chaperones govern protein homeostasis, being allied to the beginning (folding)
and ending (degradation) of the protein life cycle. Yet, the Hsp90 system primarily associates …

Repair of DNA double strand breaks (DSBs) is key for maintenance of genome integrity.
When DSBs are repaired by homologous recombination, DNA ends can undergo extensive …

Chromatin fibers are intrinsically dynamic macromolecular complexes whose biological
functions are intimately linked with their structure and interactions with chromatin-associated …

Recent biochemical studies evaluated the affinity of histones to DNA in the context of
nucleosome core particle (NCP). These have indicated a concentration-dependence for …

Depuis la caractérisation initiale du remodelage de la chromatine en tant que processus
dépendant de l'ATP, plusieurs études nous ont donné un aperçu de la façon dont les …

Recent studies of the mechanisms involved in the regulation of gene expression in eukaryotic
organisms depict a highly complex process requiring a coordinated rearrangement of …