10.7554/eLife.02523.001 Exchange of extracellular cystine for intracellular glutamate by the
antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that …

Adverse drug events remain a leading cause of morbidity and mortality around the world.
Many adverse events are not detected during clinical trials before a drug receives approval for …

The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …

Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and
public health strategies. Viral–host interactions can guide discovery of disease regulators, …

Adverse drug events cause substantial morbidity and mortality and are often discovered after
a drug comes to market. We hypothesized that Internet users may provide early clues about …

The lipid‐lowering agent pravastatin and the antidepressant paroxetine are among the most
widely prescribed drugs in the world. Unexpected interactions between them could have …

Objective Adverse drug events (ADEs) are common and account for 770 000 injuries and
deaths each year and drug interactions account for as much as 30% of these ADEs. …

Interventional pharmacology is one of medicine's most potent weapons against disease.
These drugs, however, can result in damaging side effects and must be closely monitored. …

Drug-drug interactions (DDIs) are a major cause of adverse drug effects and a public health
concern, as they increase hospital care expenses and reduce patients' quality of life. DDI …

Reduction of preventable hospital readmissions that result from chronic or acute conditions
like stroke, heart failure, myocardial infarction and pneumonia remains a significant …