User profiles for Nicholas R. Silvaggi
Nicholas R. SilvaggiAssociate Professor of Biochemistry, University of Wisconsin-Milwaukee Verified email at uwm.edu Cited by 1688 |
Double-lanthanide-binding tags: design, photophysical properties, and NMR applications
…, M Nitz, J Wöhnert, NR Silvaggi… - Journal of the …, 2007 - ACS Publications
Lanthanide-binding tags (LBTs) are peptide sequences of up to 20 encoded amino acids
that tightly and selectively complex lanthanide ions and can sensitize terbium (Tb 3+ ) …
that tightly and selectively complex lanthanide ions and can sensitize terbium (Tb 3+ ) …
Molecular basis for ADP-ribose binding to the Mac1 domain of SARS-CoV-2 nsp3
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes
numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the …
numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the …
[PDF][PDF] Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility
NR Silvaggi, GE Boldt, MS Hixon, JP Kennedy… - Chemistry & biology, 2007 - cell.com
The potential for the use of Clostridial neurotoxins as bioweapons makes the development
of small-molecule inhibitors of these deadly toxins a top priority. Recently, screening of a …
of small-molecule inhibitors of these deadly toxins a top priority. Recently, screening of a …
A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis
…, LP Kotra, ZH Li, NR Silvaggi… - Proceedings of the …, 2001 - National Acad Sciences
The cell wall imparts structural strength and shape to bacteria. It is made up of polymeric
glycan chains with peptide branches that are cross-linked to form the cell wall. The cross-linking …
glycan chains with peptide branches that are cross-linked to form the cell wall. The cross-linking …
Double-lanthanide-binding tags for macromolecular crystallographic structure determination
NR Silvaggi, LJ Martin, H Schwalbe… - Journal of the …, 2007 - ACS Publications
A double-lanthanide-binding tag (dLBT), a small peptide sequence engineered to bind two
lanthanide ions (eg, Tb 3+ ) with high affinity, was used to solve the phase problem for the …
lanthanide ions (eg, Tb 3+ ) with high affinity, was used to solve the phase problem for the …
Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins
MA McDonough, JW Anderson, NR Silvaggi… - Journal of molecular …, 2002 - Elsevier
Penicillin-binding proteins (PBPs), the target enzymes of β-lactam antibiotics such as penicillins
and cephalosporins, catalyze the final peptidoglycan cross-linking step of bacterial cell-…
and cephalosporins, catalyze the final peptidoglycan cross-linking step of bacterial cell-…
[HTML][HTML] The X-ray crystal structures of human α-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a
NR Silvaggi, C Zhang, Z Lu, J Dai… - Journal of Biological …, 2006 - ASBMB
Congential disorder of glycosylation type 1a (CDG-1a) is a congenital disease characterized
by severe defects in nervous system development. It is caused by mutations in α-…
by severe defects in nervous system development. It is caused by mutations in α-…
Discovery of drug-like ligands for the Mac1 domain of SARS-CoV-2 Nsp3
…, TR Melkonian, NR Silvaggi… - … the Science of Drug …, 2020 - journals.sagepub.com
Small molecules that bind the SARS-CoV-2 nonstructural protein 3 Mac1 domain in place of
ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug …
ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug …
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies
P Šilhár, NR Silvaggi, S Pellett, K Čapková… - Bioorganic & medicinal …, 2013 - Elsevier
… Author links open overlay panel Peter Šilhár a b , Nicholas R. Silvaggi c , Sabine Pellett d
, … Šilhár, MS Hixon, NR Silvaggi, KN Allen, ST Moe, AR Jacobson, JT Barbieri, KD Janda …
, … Šilhár, MS Hixon, NR Silvaggi, KN Allen, ST Moe, AR Jacobson, JT Barbieri, KD Janda …
Streptomyces wadayamensis MppP Is a Pyridoxal 5′-Phosphate-Dependent l-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway
l-Enduracididine (l-End) is a nonproteinogenic amino acid found in a number of bioactive
peptides, including the antibiotics teixobactin, enduracidin, and mannopeptimycin. The potent …
peptides, including the antibiotics teixobactin, enduracidin, and mannopeptimycin. The potent …