Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
…, I Lui, Y Zhang, MA Nix, NJ Rettko… - Proceedings of the …, 2020 - National Acad Sciences
An essential mechanism for severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1)
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection begins with …
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection begins with …
[HTML][HTML] Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
CJ Bracken, SA Lim, P Solomon, NJ Rettko… - Nature chemical …, 2021 - nature.com
Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and
prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic …
prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic …
Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold
…, NC Thomas, DG Belair, NJ Rettko… - Proceedings of the …, 2015 - National Acad Sciences
Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies
for selective and high-affinity recognition of large and topologically complex protein surfaces. …
for selective and high-affinity recognition of large and topologically complex protein surfaces. …
Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity
A serious public health crisis is currently unfolding due to the SARS-CoV-2 pandemic. SARS-CoV-2
viral entry depends on an interaction between the receptor binding domain of the …
viral entry depends on an interaction between the receptor binding domain of the …
Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2
SA Lim, JA Gramespacher, K Pance, NJ Rettko… - MAbs, 2021 - Taylor & Francis
Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most
directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-…
directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-…
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
LE Stopfer, NJ Rettko, O Leddy… - Proceedings of the …, 2022 - National Acad Sciences
Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma—namely MEK/BRAF
kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted immunotherapies…
kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted immunotherapies…
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
…, K Oltion, S Pourmal, GK Reder, NJ Rettko… - Biology …, 2018 - journals.biologists.com
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary
time, it is highly tolerant to mutation during selection experiments performed in the …
time, it is highly tolerant to mutation during selection experiments performed in the …
Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1)
X Ran, ET Burchfiel, B Dong, NJ Rettko… - Bioorganic & medicinal …, 2018 - Elsevier
Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that regulates expression
of protein chaperones and cell survival factors. In cancer, HSF1 plays a unique role, …
of protein chaperones and cell survival factors. In cancer, HSF1 plays a unique role, …
Engineering antibodies targeting p16 MHC-peptide complexes
NJ Rettko, J Campisi, JA Wells - ACS Chemical Biology, 2022 - ACS Publications
Senescent cells undergo a permanent cell cycle arrest and drive a host of age-related
pathologies. Recent transgenic mouse models indicate that removing cells expressing the …
pathologies. Recent transgenic mouse models indicate that removing cells expressing the …
Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence
NJ Rettko, LL Kirkemo, JA Wells - PNAS nexus, 2023 - academic.oup.com
Human leukocyte antigens (HLA) present peptides largely from intracellular proteins on cell
surfaces. As these complexes can serve as biomarkers in disease, proper identification of …
surfaces. As these complexes can serve as biomarkers in disease, proper identification of …