[HTML][HTML] Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

…, H Garner, CL Scott, A Schridde, NJ Steers… - Nature …, 2016 - nature.com
Peritoneal macrophages are one of the most studied macrophage populations in the body,
yet the composition, developmental origin and mechanisms governing the maintenance of …

[HTML][HTML] Genetic drivers of kidney defects in the DiGeorge syndrome

…, Z Yan, A Mitrotti, J Martino, NJ Steers… - … England Journal of …, 2017 - Mass Medical Soc
Background The DiGeorge syndrome, the most common of the microdeletion syndromes,
affects multiple organs, including the heart, the nervous system, and the kidney. It is caused by …

A survey of the prevalence of Escherichia coli O157 in raw meats, raw cow's milk and raw-milk cheeses in south-east Scotland

JE Coia, Y Johnston, NJ Steers, MF Hanson - International Journal of food …, 2001 - Elsevier
2429 samples of foodstuffs were examined for the presence of verocytotoxigenic Escherichia
coli O157 (VTEC O157) by means of immunomagnetic separation (IMS) over a 2-year …

Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines

CR Alving, M Rao, NJ Steers, GR Matyas… - Expert review of …, 2012 - Taylor & Francis
Liposomes containing monophosphoryl lipid A (MPLA) have previously exhibited
considerable potency and safety in human trials with a variety of candidate vaccines, including …

[HTML][HTML] Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection

NJ Steers, Y Li, Z Drace, JA D'Addario… - … England Journal of …, 2019 - Mass Medical Soc
Background In the context of kidney transplantation, genomic incompatibilities between
donor and recipient may lead to allosensitization against new antigens. We hypothesized that …

[HTML][HTML] Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

…, E Sanchez-Rodriguez, F Zanoni, Y Li, N Steers… - Nature …, 2022 - nature.com
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal
microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory …

[HTML][HTML] Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

…, ML Robb, NL Michael, DL Bolton, NJ Steers… - Nature …, 2018 - nature.com
Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent
cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence …

Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines

NJ Steers, KK Peachman, S McClain, CR Alving… - Vaccine, 2009 - Elsevier
Liposomal lipid A is an effective adjuvant for the delivery of antigens and for the induction of
both cellular and humoral immunity. In this study, we demonstrate that following the third …

[HTML][HTML] Computational and Experimental Validation of B and T-Cell Epitopes of the In Vivo Immune Response to a Novel Malarial Antigen

ES Bergmann-Leitner, S Chaudhury, NJ Steers… - PloS one, 2013 - journals.plos.org
Vaccine development efforts will be guided by algorithms that predict immunogenic epitopes.
Such prediction methods rely on classification-based algorithms that are trained against …

CD11c identifies microbiota and EGR2‐dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice

CC Bain, PA Louwe, NJ Steers… - European journal of …, 2022 - Wiley Online Library
The murine serous cavities contain a rare and enigmatic population of short‐lived F4/80 lo
MHCII + macrophages but what regulates their development, survival, and fate is unclear. …