User profiles for Nicholas Tatonetti
Nicholas P TatonettiProfessor and Vice Chair of Computational Biomedicine, Cedars-Sinai Medical Center Verified email at cshs.org Cited by 9815 |
[HTML][HTML] Associations between blood type and COVID-19 infection, intubation, and death
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …
testing resources, making the identification and prioritization of individuals most at-risk a …
[HTML][HTML] Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and
public health strategies. Viral–host interactions can guide discovery of disease regulators, …
public health strategies. Viral–host interactions can guide discovery of disease regulators, …
[HTML][HTML] Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug …
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
killed over a million people, including >25,000 in New York City (NYC) alone. The …
killed over a million people, including >25,000 in New York City (NYC) alone. The …
Artificial intelligence for drug toxicity and safety
Interventional pharmacology is one of medicine's most potent weapons against disease.
These drugs, however, can result in damaging side effects and must be closely monitored. …
These drugs, however, can result in damaging side effects and must be closely monitored. …
[HTML][HTML] Shotgun transcriptome and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions
…, LF Westblade, M Cushing, S Levy, S Wu, N Tatonetti… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused
thousands of deaths worldwide, including> 18,000 in New York City (NYC) alone. The sudden …
thousands of deaths worldwide, including> 18,000 in New York City (NYC) alone. The sudden …
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
…, M Hayano, AG Thomas, CE Gleason, NP Tatonetti… - elife, 2014 - elifesciences.org
10.7554/eLife.02523.001 Exchange of extracellular cystine for intracellular glutamate by the
antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that …
antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that …
Data-driven prediction of drug effects and interactions
Adverse drug events remain a leading cause of morbidity and mortality around the world.
Many adverse events are not detected during clinical trials before a drug receives approval for …
Many adverse events are not detected during clinical trials before a drug receives approval for …
[HTML][HTML] Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study
…, DC Crawford, J Wang, N Liu, N Tatonetti… - The Lancet, 2013 - thelancet.com
Background VKORC1 and CYP2C9 are important contributors to warfarin dose variability,
but explain less variability for individuals of African descent than for those of European or …
but explain less variability for individuals of African descent than for those of European or …
Web-scale pharmacovigilance: listening to signals from the crowd
Adverse drug events cause substantial morbidity and mortality and are often discovered after
a drug comes to market. We hypothesized that Internet users may provide early clues about …
a drug comes to market. We hypothesized that Internet users may provide early clues about …
Detecting drug interactions from adverse‐event reports: interaction between paroxetine and pravastatin increases blood glucose levels
NP Tatonetti, JC Denny, SN Murphy… - Clinical …, 2011 - Wiley Online Library
The lipid‐lowering agent pravastatin and the antidepressant paroxetine are among the most
widely prescribed drugs in the world. Unexpected interactions between them could have …
widely prescribed drugs in the world. Unexpected interactions between them could have …