Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the
fragile X mental retardation protein, which regulates signal transduction at metabotropic …

Oral sensory signals drive dietary fat intake, but the neural mechanisms underlying this
process are largely unknown. The endocannabinoid system has gained recent attention for its …

Cannabis has been used medicinally for centuries to treat a variety of disorders, including
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis-…

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach
to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age…

The ‘thrifty gene hypothesis' posits that evolution preferentially selects physiological
mechanisms that optimize energy storage to increase survival under alternating conditions of …

The endocannabinoid system is emerging as an integral component in central and peripheral
regulation of feeding and energy balance. Our investigation analyzed behavioral roles for …

The endocannabinoid system in the brain and periphery plays a major role in controlling
food intake and energy balance. We reported that tasting dietary fats was met with increased …

Free fatty acids (FFAs) suppress appetite when injected into the hypothalamus. To examine
whether lipoprotein lipase (LPL), a serine hydrolase that releases FFAs from circulating …

Fat is a vital macronutrient, and its intake is closely monitored by an array of molecular sensors
distributed throughout the alimentary canal. In the mouth, dietary fat constituents such as …

The endocannabinoid system plays a critical role in the control of energy homeostasis, but
the identity and localization of the endocannabinoid signal involved remain unknown. In the …