Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility
INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a representative …
nonhuman primate (NHP) models for studying human biology and disease. As a representative …
Continuous chromosome-scale haplotypes assembled from a single interspecies F1 hybrid of yak and cattle
Background The development of trio binning as an approach for assembling diploid genomes
has enabled the creation of fully haplotype-resolved reference genomes. Unlike other …
has enabled the creation of fully haplotype-resolved reference genomes. Unlike other …
Fine-Mapping Complex Inversion Breakpoints and Investigating Somatic Pairing in the Anopheles gambiae Species Complex Using Proximity-Ligation Sequencing
…, M Calzetta, M Genetti, J McBroome, NW Maurer… - Genetics, 2019 - academic.oup.com
In this work, Corbett-Detig et al. use proximity-ligation sequencing (Hi-C) of several
Anopheles gambiae and A. coluzzii inversionbearing individuals to detect and map inversion …
Anopheles gambiae and A. coluzzii inversionbearing individuals to detect and map inversion …
Whole-genome sequence and assembly of the Javan gibbon (Hylobates moloch)
M Escalona, J VanCampen, NW Maurer… - Journal of …, 2023 - academic.oup.com
The Javan gibbon, Hylobates moloch, is an endangered gibbon species restricted to the forest
remnants of western and central Java, Indonesia, and one of the rarest of the Hylobatidae …
remnants of western and central Java, Indonesia, and one of the rarest of the Hylobatidae …
Chromosome-length haplotigs for yak and cattle from trio binning assembly of an F1 hybrid
Background Assemblies of diploid genomes are generally unphased, pseudo-haploid
representations that do not correctly reconstruct the two parental haplotypes present in the …
representations that do not correctly reconstruct the two parental haplotypes present in the …
[HTML][HTML] Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes
De novo assembly of a human genome using nanopore long-read sequences has been
reported, but it used more than 150,000 CPU hours and weeks of wall-clock time. To enable …
reported, but it used more than 150,000 CPU hours and weeks of wall-clock time. To enable …
[HTML][HTML] Highly accurate long-read HiFi sequencing data for five complex genomes
…, YC Tsai, JW Karalius, JM Landolin, N Maurer… - Scientific data, 2020 - nature.com
The PacBio ® HiFi sequencing method yields highly accurate long-read sequencing datasets
with read lengths averaging 10–25 kb and accuracies greater than 99.5%. These accurate …
with read lengths averaging 10–25 kb and accuracies greater than 99.5%. These accurate …
[HTML][HTML] Early preclinical detection of prions in the skin of prion-infected animals
…, NR Maurer, P Gambetti, B Xu, W Surewicz… - Nature …, 2019 - nature.com
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection
currently and no validated alternative preclinical diagnostic tests have been reported to …
currently and no validated alternative preclinical diagnostic tests have been reported to …
[HTML][HTML] Artificial strain of human prions created in vitro
The molecular mechanism that determines under physiological conditions transmissibility of
the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD) is …
the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD) is …
One fly–one genome: chromosome-scale genome assembly of a single outbred Drosophila melanogaster
M Adams, J McBroome, N Maurer… - Nucleic acids …, 2020 - academic.oup.com
A high quality genome assembly is a vital first step for the study of an organism. Recent
advances in technology have made the creation of high quality chromosome scale assemblies …
advances in technology have made the creation of high quality chromosome scale assemblies …