Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

As life expectancy of people with intellectual disabilities (ID) extends into older age, dementia
is an increasing cause of morbidity and mortality. To update and summarize current …

We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find …

Objective: Family and twin studies suggest that liability for suicide attempts is heritable and
distinct from mood disorder susceptibility. The authors therefore examined the association …

We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions (DMPs) …

Objective: Lithium remains a first-line treatment for bipolar disorder, but the mechanisms by
which it prevents the recurrence of mood episodes are not known. The authors utilized data …

Objective Dementia is a common clinical presentation among older adults with Down
syndrome. The presentation of dementia in Down syndrome differs compared with typical …

BackgroundCopy number variants (CNVs) are established risk factors for neurodevelopmental
disorders. To date the study of CNVs in psychiatric illness has focused on single disorder …

Most genome-wide association studies (GWAS) of major depression (MD) have been conducted
in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding …