Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery
…, A Linteau, S Sillaots, C Marta, N Martel… - Molecular …, 2003 - Wiley Online Library
Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs
to combat fungal infections [Sobel, JD (2000) Clin Infectious Dis 30: 652], antifungal drug …
to combat fungal infections [Sobel, JD (2000) Clin Infectious Dis 30: 652], antifungal drug …
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
…, O Tort, A Gubern, RM Templin, JEB Curson, N Martel… - Science, 2020 - science.org
INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …
[HTML][HTML] Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
…, T Ketela, S Lemieux, K Veillette, N Martel… - PLoS …, 2007 - journals.plos.org
Candida albicans is a prevalent fungal pathogen amongst the immunocompromised
population, causing both superficial and life-threatening infections. Since C. albicans is diploid, …
population, causing both superficial and life-threatening infections. Since C. albicans is diploid, …
The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle
…, M Bastiani, M Floetenmeyer, N Martel… - Journal of Cell …, 2015 - rupress.org
Dysfunction of caveolae is involved in human muscle disease, although the underlying
molecular mechanisms remain unclear. In this paper, we have functionally characterized mouse …
molecular mechanisms remain unclear. In this paper, we have functionally characterized mouse …
[PDF][PDF] Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms
…, TE Hall, J Rae, C Ferguson, KA McMahon, N Martel… - Developmental cell, 2015 - cell.com
Reliable and quantifiable high-resolution protein localization is critical for understanding
protein function. However, the time required to clone and characterize any protein of interest is …
protein function. However, the time required to clone and characterize any protein of interest is …
Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
Caveolae have been linked to many biological functions, but their precise roles are unclear.
Using quantitative whole-cell proteomics of genome-edited cells, we show that the oxidative …
Using quantitative whole-cell proteomics of genome-edited cells, we show that the oxidative …
The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue
…, RL Fitzsimmons, JM Goode, N Martel… - Molecular …, 2012 - academic.oup.com
Nuclear hormone receptors (NR) have been implicated as regulators of lipid and carbohydrate
metabolism. The orphan NR4A subgroup has emerged as regulators of metabolic function…
metabolism. The orphan NR4A subgroup has emerged as regulators of metabolic function…
[PDF][PDF] Caveolae protect notochord cells against catastrophic mechanical failure during development
YW Lim, HP Lo, C Ferguson, N Martel, J Giacomotto… - Current Biology, 2017 - cell.com
The embryonic notochord is a flexible structure present during development that serves as
scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved in …
scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved in …
[PDF][PDF] Caveolin‐1 orchestrates the balance between glucose and lipid‐dependent energy metabolism: implications for liver regeneration
…, C Restall, C Ferguson, N Martel… - …, 2012 - Wiley Online Library
Caveolin‐1 (CAV1) is a structural protein of caveolae involved in lipid homeostasis and
endocytosis. Using newly generated pure Balb/C CAV1 null ( Balb/C CAV1−/−) mice, CAV1−/− …
endocytosis. Using newly generated pure Balb/C CAV1 null ( Balb/C CAV1−/−) mice, CAV1−/− …
An actin filament population defined by the tropomyosin Tpm3. 1 regulates glucose uptake
AJ Kee, L Yang, CA Lucas, MJ Greenberg, N Martel… - Traffic, 2015 - Wiley Online Library
Actin has an ill‐defined role in the trafficking of GLUT4 glucose transporter vesicles to the
plasma membrane ( PM ). We have identified novel actin filaments defined by the tropomyosin …
plasma membrane ( PM ). We have identified novel actin filaments defined by the tropomyosin …