The metal-catalyzed addition of aromatic substrates to electron deficient σ-and π-systems,
commonly known as Friedel-Crafts alkylation, 1 has long been established as a powerful …

The first enantioselective organocatalytic alkylation of electron-rich benzene rings with α,β-unsaturated
aldehydes has been accomplished. The use of iminium catalysis has provided a …

AMG 176 is a potent, selective, and orally bioavailable MCL1 inhibitor that induces a rapid
commitment to apoptosis in models of hematologic malignancies. The synergistic …

Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark
of Alzheimer’s disease (AD) and many other neurodegenerative tauopathies. The filaments …

The development of enantioselective Lewis acid catalyzed carbonyl addition reactions of π-nucleophiles
such as enolsilanes and allylstannanes is a topic of current interest. 1 The …

The α-synuclein protein can adopt several different conformations that cause
neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: …

The C 2 -symmetric complexes [Cu(S,S)-tert-butylbis(oxazolinyl)](SbF 6 ) 2 (2a), its bis(aquo)
counterpart [Cu(S,S)-tert-butylbis(oxazolinyl)(H 2 O) 2 ](SbF 6 ) 2 (4), and [Cu(S,S)-…

The discovery and optimization of a novel series of aminoisoquinolines as potent, selective,
and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked …

Parkinson’s disease (PD) is a common neurodegenerative disorder without effective
disease-modifying therapeutics. Here, we establish a chemogenetic dopamine (DA) neuron …

Prions were initially discovered in studies of scrapie, a transmissible neurodegenerative
disease (ND) of sheep and goats thought to be caused by slow viruses. Once scrapie was …