Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Proximal spinal muscular atrophy (SMA) is a common autosomal recessive childhood form
of motor neuron disease. Previous studies have highlighted nerve- and muscle-specific …

The whirler mouse mutant (wi) does not respond to sound stimuli, and detailed ultrastructural
analysis of sensory hair cells in the organ of Corti of the inner ear indicates that the whirler …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care 1 or hospitalization 2 , 3 – …

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian
genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we …

The construction of parallel archives of DNA and sperm from mice mutagenized with
ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point …

Mutations in the charged multivesicular body protein 2B (CHMP2B) gene cause frontotemporal
lobar degeneration. The mutations lead to C-terminal truncation of the CHMP2B protein. …

N-ethyl-N-nitrosourea (ENU) introduces mutations throughout the mouse genome at relatively
high efficiency. Successful high-throughput phenotype screens have been reported and …

The mechanotransduction process in hair cells in the inner ear is associated with the influx
of calcium from the endolymph. Calcium is exported back to the endolymph via the splice …

Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host
immune system. We and others have shown that host genetic variation influences the …