Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected

K Saito, S Mishra, T Warrier, N Cicchetti, J Mi… - Science translational …, 2021 - science.org
“Viable but nonculturable” states of bacteria pose challenges for environmental and clinical
microbiology, but their biological mechanisms remain obscure. Mycobacterium tuberculosis (…

Multiplexed strain phenotyping defines consequences of genetic diversity in Mycobacterium tuberculosis for infection and vaccination outcomes

AF Carey, X Wang, N Cicchetti, CN Spaulding, Q Liu… - Msystems, 2022 - Am Soc Microbiol
There is growing evidence that genetic diversity in Mycobacterium tuberculosis , the
causative agent of tuberculosis, contributes to the outcomes of infection and public health …

Utilizing 3-D Printing to Create Micro-Physiological Systems

NA Cicchetti - 2017 - search.proquest.com
The fabrication of microfluidic devices is an important process for researchers in the biomedical
engineering field. These devices must exhibit high levels of reproducibility and precision …

Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats

F Cicchetti, N Lapointe, A Roberge-Tremblay… - Neurobiology of …, 2005 - Elsevier
In recent years, several lines of evidence have shown an increase in Parkinson's disease (PD)
prevalence in rural environments where pesticides are widely used. Paraquat (PQ—…

Mutant huntingtin is present in neuronal grafts in Huntington disease patients

F Cicchetti, S Lacroix, G Cisbani, N Vallières… - Annals of …, 2014 - Wiley Online Library
Objective Huntington disease (HD) is caused by a genetically encoded pathological protein
(mutant huntingtin [mHtt]), which is thought to exert its effects in a cell‐autonomous manner. …

Rotenone induces non‐specific central nervous system and systemic toxicity

…, J Blanchet, P Gould, C Rouillard, F Cicchetti - The FASEB …, 2004 - Wiley Online Library
We investigated the dopaminergic (DA) neuronal degeneration in animals subjected to
systemic treatment of rotenone via subcutaneous delivery. Behavioral observations revealed a …

[HTML][HTML] SIMBIO-SYS: scientific cameras and spectrometer for the BepiColombo mission

…, C Carli, V Carlier, P Cerroni, A Cicchetti… - Space science …, 2020 - Springer
The SIMBIO-SYS (Spectrometer and Imaging for MPO BepiColombo Integrated Observatory
SYStem) is a complex instrument suite part of the scientific payload of the Mercury Planetary …

Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease

…, M Panisset, RA Barker, E Boilard, F Cicchetti - Neurobiology of …, 2019 - Elsevier
The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but
pathological events can affect their formation and constituents. We sought to characterize the …

[HTML][HTML] Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases

…, Y De Koninck, A Droit, F Cicchetti… - Journal of Experimental …, 2020 - rupress.org
Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis (RA), …

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

…, T Perlmann, SL Ang, F Cicchetti… - Proceedings of the …, 2016 - National Acad Sciences
The LIM-homeodomain transcription factors Lmx1a and Lmx1b play critical roles during the
development of midbrain dopaminergic progenitors, but their functions in the adult brain …