Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no
pharmaceutical intervention is available to attenuate the cartilage degeneration. To identify a new …

Objective Identify gene expression profiles associated with OA processes in articular cartilage
and determine pathways changing during the disease process. Methods Genome wide …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and
type 2 diabetes as identified by genome-wide association studies was tested for compatibility …

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA)
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …

We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …

Objectives To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis
(OA) onset in humans and to explore whether counteracting the deleterious effect could …

Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have
implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-…