Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …

Human monocytes are divided in three major populations; classical (CD14 + CD16 − ), non-classical
(CD14 dim CD16 + ), and intermediate (CD14 + CD16 + ). Each of these subsets is …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…

The tight regulation of microglia activity is key for precise responses to potential threats, while
uncontrolled and exacerbated microglial activity is neurotoxic. Microglial toll‐like receptors …

Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive
pulmonary disease (COPD) are far from being understood. Here, we determine disease-…

‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes
Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the …

Introduction People living with HIV (PLHIV) are characterized by functional reprogramming
of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess …

Blastocyst-derived stem cell lines were shown to self-organize into embryo-like structures in
3D cell culture environments. Here, we provide evidence that embryo-like structures can be …