Squaring the circle: circRNAs in melanoma
N Mecozzi, O Vera, FA Karreth - Oncogene, 2021 - nature.com
Non-coding RNAs are emerging as critical molecules in the genesis, progression, and therapy
resistance of cutaneous melanoma. This includes circular RNAs (circRNAs), a class of …
resistance of cutaneous melanoma. This includes circular RNAs (circRNAs), a class of …
[HTML][HTML] A MAPK/miR-29 axis suppresses melanoma by targeting MAFG and MYBL2
Simple Summary The miR-29 family is subjected to complex regulation by tumor suppressors
and oncogenes and has tumor suppressive potential in several cancers. We demonstrate …
and oncogenes and has tumor suppressive potential in several cancers. We demonstrate …
Genetic tools for the stable overexpression of circular RNAs
N Mecozzi, A Nenci, O Vera, I Bok, A Falzone… - RNA biology, 2022 - Taylor & Francis
Circular RNAs (circRNAs) are a class of non-coding RNAs featuring a covalently closed ring
structure formed through backsplicing. circRNAs are broadly expressed and contribute to …
structure formed through backsplicing. circRNAs are broadly expressed and contribute to …
PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis
PTEN suppresses melanoma predominantly through its lipid phosphatase function, which
when lost, elevates FRA1 levels through AKT/mTOR signaling to promote several aspects of …
when lost, elevates FRA1 levels through AKT/mTOR signaling to promote several aspects of …
[PDF][PDF] MAPK-induced miR-29 restrains melanoma progression by targeting MAFG
The tumor suppressive miR-29 family of microRNAs is encoded by two clusters, miR-29b1~
a and miR-29b2~ c, which are regulated by oncogenic and tumor suppressive stimuli, …
a and miR-29b2~ c, which are regulated by oncogenic and tumor suppressive stimuli, …
MAPK-induced miR-29 targets MAFG and suppresses melanoma progression
The tumor suppressive miR-29 family of microRNAs is encoded by two clusters, miR-29b1~a
and miR-29b2~c, and is regulated by several oncogenic and tumor suppressive stimuli. …
and miR-29b2~c, and is regulated by several oncogenic and tumor suppressive stimuli. …
circPMS1 is a pro-metastatic circular RNA in melanoma
N Mecozzi, O Vera, F Karreth - Cancer Research, 2023 - AACR
Deregulated gene expression is a major driver of melanoma metastasis, a process that results
in the majority of melanoma-related deaths. Importantly, these alterations are not limited …
in the majority of melanoma-related deaths. Importantly, these alterations are not limited …
MAPK-induced miR-29 targets MAFG and suppresses melanoma development
The tumor suppressive miR-29 family of microRNAs is encoded by two clusters, miR-29b1∼a
and miR-29b2∼c, which are regulated by oncogenic and tumor suppressive stimuli, …
and miR-29b2∼c, which are regulated by oncogenic and tumor suppressive stimuli, …
Identification and characterization of novel circRNAs involved in melanoma
N MECOZZI - 2020 - etd.adm.unipi.it
Circular RNAs (circRNAs) are a novel class of RNA molecules characterized by circular
structures, meaning they lack 3’end and 5’ends, polyadenylated tails, and 5’CAPs. Because of …
structures, meaning they lack 3’end and 5’ends, polyadenylated tails, and 5’CAPs. Because of …
To fly as a pilot after cardiac surgery
T Syburra, E Nicol, S Mitchell, D Bron… - European Journal of …, 2018 - academic.oup.com
Aircrew are responsible for safe and reliable aircraft operations. Cardiovascular disease
accounts for 50% of all pilot licences declined or withdrawn for medical reasons in Western …
accounts for 50% of all pilot licences declined or withdrawn for medical reasons in Western …