To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum,
we conducted a meta-analysis of genome-wide association data from 26,676 T2D case …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and
57,574 controls of European ancestry. We identified 49 distinct association signals at these …

Proteins are composed of evolutionary units called domains; the majority of proteins consist
of at least two domains. These domains and nature of their interactions determine the …

Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …

In this study, Wareham and colleagues quantified the combined effects of genetic and lifestyle
factors on risk of T2D in order to inform strategies for prevention. The authors found that …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form
of clonal mosaicism 1 , 2 , 3 , 4 – 5 , yet our knowledge of the causes and consequences of …

Genome-wide association analysis advanced understanding of blood pressure (BP), a major
risk factor for vascular conditions such as coronary heart disease and stroke. Accounting …

The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …

Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However,
the causality of this relationship and the biological mechanisms that underlie it are unclear. …