[HTML][HTML] Does skin surface temperature variation account for Buruli ulcer lesion distribution?
NK Sexton-Oates, AJ Stewardson… - PLoS neglected …, 2020 - journals.plos.org
Background Buruli ulcer is a necrotising infection of skin and soft tissue caused by Mycobacterium
ulcerans (M. ulcerans). Buruli ulcer most often occurs on limbs, and it is hypothesized …
ulcerans (M. ulcerans). Buruli ulcer most often occurs on limbs, and it is hypothesized …
[HTML][HTML] Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing data, …
challenging clinical management. Through a large series of whole-genome sequencing data, …
Multi-omic characterisation of clear cell renal carcinoma reveals endogenous and exogenous processes related to its aetiology
Endogenous and exogenous exposures are associated with distinctive molecular marks in
somatic tissues, including human tumours. Integrative multi-omic approaches could help …
somatic tissues, including human tumours. Integrative multi-omic approaches could help …
[PDF][PDF] Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites
…, WM Hackeng, K Samsom, C Voegele, A Sexton-Oates… - Cancer cell, 2023 - cell.com
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs)
and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms
Background Organoids are 3-dimensional experimental models that summarize the
anatomical and functional structure of an organ. Although a promising experimental model for …
anatomical and functional structure of an organ. Although a promising experimental model for …
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms
Background: Organoids are three-dimensional experimental models that summarize the
anatomical and functional structure of an organ. Although a promising experimental model for …
anatomical and functional structure of an organ. Although a promising experimental model for …
Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer
…, WM Hackeng, K Samsom, C Voegele, A Sexton-Oates… - bioRxiv, 2022 - biorxiv.org
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors and
poorly-differentiated carcinomas. Treatment options for patients with NENs are limited, in …
poorly-differentiated carcinomas. Treatment options for patients with NENs are limited, in …
A molecular phenotypic map of malignant pleural mesothelioma
Background Malignant pleural mesothelioma (MPM) is a rare understudied cancer associated
with exposure to asbestos. So far, MPM patients have benefited marginally from the …
with exposure to asbestos. So far, MPM patients have benefited marginally from the …
Disease aetiology and progression shape the inter-patient multi-omics profile of clear cell renal carcinoma
J McKay, R Penha, A Sexton-Oates, S Senkin, H Park… - 2024 - researchsquare.com
Endogenous and exogenous processes are associated with distinctive molecular marks in
somatic tissues, including human tumours. Here, we used integrative multi-omics analyses to …
somatic tissues, including human tumours. Here, we used integrative multi-omics analyses to …
Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses
Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Using the largest series of whole-genome sequencing data …
challenging clinical management. Using the largest series of whole-genome sequencing data …