[HTML][HTML] Does skin surface temperature variation account for Buruli ulcer lesion distribution?

NK Sexton-Oates, AJ Stewardson… - PLoS neglected …, 2020 - journals.plos.org
Background Buruli ulcer is a necrotising infection of skin and soft tissue caused by Mycobacterium
ulcerans (M. ulcerans). Buruli ulcer most often occurs on limbs, and it is hypothesized …

[HTML][HTML] Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity

L Mangiante, N Alcala, A Sexton-Oates, A Di Genova… - Nature Genetics, 2023 - nature.com
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing data, …

Multi-omic characterisation of clear cell renal carcinoma reveals endogenous and exogenous processes related to its aetiology

…, S Senkin, H La Park, N Alcala, M Foll, K Smith-Byrne… - Cancer Research, 2024 - AACR
Endogenous and exogenous exposures are associated with distinctive molecular marks in
somatic tissues, including human tumours. Integrative multi-omic approaches could help …

[PDF][PDF] Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites

…, WM Hackeng, K Samsom, C Voegele, A Sexton-Oates… - Cancer cell, 2023 - cell.com
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs)
and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms

…, C Voegele, L Mangiante, A Sexton-Oates… - …, 2024 - academic.oup.com
Background Organoids are 3-dimensional experimental models that summarize the
anatomical and functional structure of an organ. Although a promising experimental model for …

Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms

N Alcala, C Voegele, L Mangiante, A Sexton-Oates… - bioRxiv, 2023 - biorxiv.org
Background: Organoids are three-dimensional experimental models that summarize the
anatomical and functional structure of an organ. Although a promising experimental model for …

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

…, WM Hackeng, K Samsom, C Voegele, A Sexton-Oates… - bioRxiv, 2022 - biorxiv.org
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors and
poorly-differentiated carcinomas. Treatment options for patients with NENs are limited, in …

A molecular phenotypic map of malignant pleural mesothelioma

A Di Genova, L Mangiante, A Sexton-Oates… - …, 2023 - academic.oup.com
Background Malignant pleural mesothelioma (MPM) is a rare understudied cancer associated
with exposure to asbestos. So far, MPM patients have benefited marginally from the …

Disease aetiology and progression shape the inter-patient multi-omics profile of clear cell renal carcinoma

J McKay, R Penha, A Sexton-Oates, S Senkin, H Park… - 2024 - researchsquare.com
Endogenous and exogenous processes are associated with distinctive molecular marks in
somatic tissues, including human tumours. Here, we used integrative multi-omics analyses to …

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

L Mangiante, N Alcala, A Di Genova, A Sexton-Oates… - bioRxiv, 2021 - biorxiv.org
Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Using the largest series of whole-genome sequencing data …