The primate cerebrum is characterized by a large expansion of cortical surface area, the
formation of convolutions, and extraordinarily voluminous subcortical white matter. It was …

Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation
and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 …

Better understanding of the progression of neural stem cells (NSCs) in the developing
cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of …

Radial glial cells (RGC) are at the center of brain development in vertebrates, acting as
progenitors for neurons and macroglia (oligodendrocytes and astrocytes) and as guides for …

The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity,
nuclear localization, and likely, function in development. To understand the in vivo role of …

During early telencephalic development, intricate processes of regional patterning and
neural stem cell (NSC) fate specification take place. However, our understanding of these …

The primary stem cells of the cerebral cortex are the radial glial cells (RGCs), and disturbances
in their operation lead to myriad brain disorders in all mammals from mice to humans. …

Prep1 is a homeodomain transcription factor that is essential in embryonic development
and functions in the adult as a tumor suppressor. We show here that Prep1 is involved in …

The ex vivo expansion of stem cells is making major contribution to biomedical research.
The multipotent nature of neural precursors acutely isolated from the developing central …

PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is
overexpressed in some DS tissues and might be involved in the DS phenotype. By using …