A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular
disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T H 17) cells…

Background: Arterial hypertension and its organ sequelae show characteristics of T cell–mediated
inflammatory diseases. Experimental anti-inflammatory therapies have been shown to …

Growing empirical evidence suggests that nutrition and bacterial metabolites might impact the
systemic immune response in the context of disease and autoimmunity. We report that long…

Sodium intake is undoubtedly indispensable for normal body functions but can be detrimental
when taken in excess of dietary requirements. The consequences of excessive salt intake …

Aims Increased levels of reactive oxygen species cause oxidative stress and severely damage
lipids, proteins, and DNA. We have previously shown that partial proteasome inhibition …

A vast number of studies have demonstrated a remarkable role for the gut microbiota and
their metabolites in the pathogenesis of inflammatory diseases, including multiple sclerosis (MS…

The pathogenesis of hypertension is known to involve a diverse range of contributing factors
including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to …

Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet.
Here we show in the substudy of NCT02099968, investigating the clinical parameters, the …

During tissue inflammation, immune cells infiltrate the interstitial space of target organs,
where they sense and adapt to local environmental stimuli. Such stimuli include not only …

Recent preclinical and observational cohort studies have implicated imbalances in gut
microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex …