The evolution in next-generation sequencing (NGS) technology has led to the development
of many different assembly algorithms, but few of them focus on assembling the organelle …

COLOMBOS is a database that integrates publicly available transcriptomics data for several
prokaryotic model organisms. Compared to the previous version it has more than doubled in …

Orchidaceae is one of the largest families of angiosperms. Considering the large number of
species in this family and its symbiotic relationship with fungi, Orchidaceae provide an ideal …

Background During normal zygotic division, two haploid parental genomes replicate, unite
and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental …

Accurate simulations of structural variation distributions and sequencing data are crucial for
the development and benchmarking of new tools. We develop Sim-it, a straightforward tool …

Heteroplasmy, the existence of multiple mitochondrial haplotypes within an individual, has
been studied across different scientific fields. Mitochondrial genome polymorphisms have …

Segmental duplications or low copy repeats (LCRs) constitute duplicated regions interspersed
in the human genome, currently neglected in standard analyses due to their extreme …

Abstract Development of primary mediastinal B‐cell lymphoma (PMBL) is driven by cumulative
genomic aberrations. We discovered a unique copy‐neutral loss of heterozygosity (CN‐…

The 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion disorder.
Why the incidence of 22q11.2DS is much greater than that of other genomic disorders …

The zygotic division enables two haploid genomes to segregate into two biparental diploid
blastomeres. This fundamental tenet was challenged by the observation that blastomeres …