We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell.
This method is based on the construction of a three-dimensional digital model cell from …

Movement of particles in cell nuclei can be affected by viscosity, directed flows, active
transport, or the presence of obstacles such as the chromatin network. Here we investigate …

The habenular neural circuit is attracting increasing attention from researchers in fields as
diverse as neuroscience, medicine, behavior, development, and evolution. Recent studies …

Background The conserved habenular neural circuit relays cognitive information from the
forebrain into the ventral mid- and hindbrain. In zebrafish, the bilaterally formed habenulae in …

The nucleus of interphase eukaryotic cell is a highly compartmentalized structure containing
the three-dimensional network of chromatin and numerous proteinaceous subcompartments…

10.7554/eLife.29173.001 Most organs rely on stem cells to maintain homeostasis during
post-embryonic life. Typically, stem cells of independent lineages work coordinately within …

The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously
deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)‐mutant and 1p/19q‐…

Animal organs are typically formed during embryogenesis by following one specific developmental
programme. Here, we report that neuromast organs are generated by two distinct and …

Simple Summary The excessive desmoplasia is the hallmark of human pancreatic cancer
that influences the local T-cell-based immune response. In the present work, the stromal …

Most neuronal populations form on both the left and right sides of the brain. Their efferent
axons appear to grow synchronously along similar pathways on each side, although the …