Receptor site-3 on voltage-gated sodium channels is targeted by a variety of structurally
distinct toxins from scorpions, sea anemones, and spiders whose typical action is the inhibition …

Six peptide toxins (Magi 1–6) were isolated from the Hexathelidae spider Macrothele gigas.
The amino acid sequences of Magi 1, 2, 5 and 6 have low similarities to the amino acid …

Animal venoms are highly complex mixtures that can contain many disulfide-bridged toxins.
This work presents an LC-MALDI approach allowing (1) a rapid classification of toxins …

Scorpion β-toxins that affect the activation of mammalian voltage-gated sodium channels (Na
v s) have been studied extensively, but little is known about their functional surface and …

Despite the noxious effects inflicted by Dinoponera ant's envenomation, the information about
the biological properties and composition of their venom is still very limited. Ants from the …

Scorpion α-toxins are similar in their mode of action and three-dimensional structure but differ
considerably in affinity for various voltage-gated sodium channels (NaChs). To clarify the …

Background and purpose: Venoms are a rich source of ligands for ion channels, but very little
is known about their capacity to modulate G‐protein coupled receptor (GPCR) activity. We …

Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and
death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-…

Background Animal venoms are complex molecular cocktails containing a wide range of
biologically active disulphide-reticulated peptides that target, with high selectivity and efficacy, a …

Background Animal venoms are large, complex libraries of bioactive, disulphide-rich peptides.
These peptides, and their novel biological activities, are of increasing pharmacological …