Mediator (MED) is a conserved multisubunit complex bridging transcriptional activators and
repressors to the general RNA polymerase II initiation machinery. In yeast, MED is organized …

Background The sodium/glucose cotransporter 2 inhibitor empagliflozin has cardiorenal
protective properties through mechanisms beyond glucose control. In this study we assessed …

Neural circuits are refined by both functional and structural changes. Structural remodeling
by large-scale pruning occurs where relatively long neuronal branches are cut away from …

Large-scale pruning, the removal of long neuronal processes, is deployed widely within the
developing nervous system and is essential for proper circuit formation. In Drosophila the …

Background Disturbances in renal microcirculation play an important role in the pathophysiology
of chronic kidney disease (CKD), but the lack of easy accessible techniques hampers …

Objective: There is increasing evidence that sodium can be stored in the skin and muscles
without being osmotically active, yet whether acute changes in dietary sodium intake alter …

Forkhead box (FOXO) proteins are evolutionarily conserved, stress-responsive transcription
factors (TFs) that can promote or counteract cell death. Mutations in FOXO genes are …

Progressive degeneration of dopaminergic (DA) neurons in the substantia nigra is a
hallmark of Parkinson’s disease (PD). Dysregulation of developmental transcription factors is …

Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin
C), two subunits of the conserved Mediator (MED) complex, have been linked to diverse …

Les aléas côtiers (érosion, submersion, migration dunaire) et les dynamiques côtières sont
souvent méconnus par le grand public. Or, dans un contexte de changement climatique et d’…