User profiles for Nicolas Lonfat
 | Nicolas LonfatHarvard Medical School Verified email at genetics.med.harvard.edu Cited by 420 |
Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci
Hox genes are required during the morphogenesis of both vertebrate digits and external
genitals. We investigated whether transcription in such distinct contexts involves a shared …
genitals. We investigated whether transcription in such distinct contexts involves a shared …
A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus
During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy
involving two topologically associating domains (TADs) located on either side of the gene …
involving two topologically associating domains (TADs) located on either side of the gene …
[HTML][HTML] Structure, function and evolution of topologically associating domains (TADs) at HOX loci
Hox genes encode transcription factors necessary for patterning the major developing anterior
to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of …
to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of …
Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina
Transcription factors (TFs) are often used repeatedly during development and homeostasis
to control distinct processes in the same and/or different cellular contexts. Considering the …
to control distinct processes in the same and/or different cellular contexts. Considering the …
Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types
Identification of cell type-specific cis-regulatory elements (CREs) is crucial for understanding
development and disease, although identification of functional regulatory elements remains …
development and disease, although identification of functional regulatory elements remains …
[HTML][HTML] A Genetic Approach to the Recruitment of PRC2 at the HoxD Locus
Polycomb group (PcG) proteins are essential for the repression of key factors during early
development. In Drosophila, the polycomb repressive complexes (PRC) associate with …
development. In Drosophila, the polycomb repressive complexes (PRC) associate with …
Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors
The vertebrate retina is generated by retinal progenitor cells (RPCs), which produce >100
cell types. Although some RPCs produce many cell types, other RPCs produce restricted …
cell types. Although some RPCs produce many cell types, other RPCs produce restricted …
Transgene-and locus-dependent imprinting reveals allele-specific chromosome conformations
When positioned into the integrin α-6 gene, an Hoxd9lacZ reporter transgene displayed
parental imprinting in mouse embryos. While the expression from the paternal allele was …
parental imprinting in mouse embryos. While the expression from the paternal allele was …
Cell type- and stage-specific expression of Otx2 is coordinated by a cohort of transcription factors and multiple cis-regulatory modules in the retina
Transcription factors (TFs) are often used repeatedly during development and homeostasis
to control distinct processes in the same and/or different cellular contexts. Considering the …
to control distinct processes in the same and/or different cellular contexts. Considering the …
[PDF][PDF] Epigenomics of retinal development in mice and humans
N Lonfat, C Cepko - Neuron, 2017 - cell.com
… Nicolas Lonfat1 and Connie Cepko1,2,* 1Departments of Genetics and Ophthalmology
2Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA *Correspondence …
2Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA *Correspondence …