Due to evolutionary conservation of biology, experimental knowledge captured from genetic
studies in eukaryotic model organisms provides insight into human cellular pathways and …

10.7554/eLife.42670.001 Bacterial spillage into a sterile environment following intestinal
hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically …

Purpose: Radioresistance of cancer cells remains a fundamental barrier for maximum
efficient radiotherapy. Tumor heterogeneity and the existence of distinct cell subpopulations …

Multicellular spheroids represent a well-established 3D model to study healthy and
diseased cells in vitro. The use of conventional 3D cell culture platforms for the generation of …

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent
bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated …

Background & Aims High-dose irradiation is an essential tool to help control the growth of
hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening …

Paracrine signalling mediated by cytokine secretion is essential for liver regeneration after
hepatic resection, yet the mechanisms of cellular crosstalk between immune and …

The toll-like receptor 5 (TLR5) agonist, CBLB502/Entolimod, is a peptide derived from
bacterial flagellin and has been shown to protect against radiation-induced tissue damage in …

Assessing similarity is highly important for bioinformatics algorithms to determine correlations
between biological information. A common problem is that similarity can appear by chance…

Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse
model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the …