Transcription factors are central to sustaining pluripotency, yet little is known about
transcription factor dynamics in defining pluripotency in the early mammalian embryo. Here, we …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis, …

Compaction of the preimplantation embryo is the earliest morphogenetic process essential
for mammalian development, yet it remains unclear how round cells elongate to form a …

Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it
remains unknown how the dynamics of TF-DNA interactions change during cell-fate …

BACKGROUND: The rostral anterior cingulate cortex (rACC) and the amygdala consistently
emerge from neuroimaging studies as brain regions crucially involved in normal and …

Every cell in our body originates from the pluripotent inner mass of the embryo, yet it is
unknown how biomechanical forces allocate inner cells in vivo. Here we discover subcellular …

Transformation from morula to blastocyst is a defining event of preimplantation embryo
development. During this transition, the embryo must establish a paracellular permeability barrier …

Neural tube (NT) defects arise from abnormal neurulation and result in the most common
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown due …

To implant in the uterus, the mammalian embryo first specifies two cell lineages: the pluripotent
inner cell mass that forms the fetus, and the outer trophectoderm layer that forms the …

The cytoskeleton — comprising actin filaments, microtubules and intermediate filaments —
serves instructive roles in regulating cell function and behaviour during development. …