User profiles for Nicole A. J. Krentz
Nicole KrentzAssistant Professor, Faculty of Pharmaceutical Sciences, University of British Columbia Verified email at ubc.ca Cited by 627 |
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
NAJ Krentz, AL Gloyn - Nature Reviews Endocrinology, 2020 - nature.com
Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis. …
both genetic and environmental risk factors, resulting in impaired glucose homeostasis. …
Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering
Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8),
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
[PDF][PDF] Single-cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors
Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …
[PDF][PDF] Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors
NAJ Krentz, D van Hoof, Z Li, A Watanabe, M Tang… - Developmental cell, 2017 - cell.com
During pancreatic development, proliferating pancreatic progenitors activate the proendocrine
transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into …
transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into …
[HTML][HTML] PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
HH Lau, NAJ Krentz, F Abaitua… - Nature …, 2023 - nature.com
The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered
risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta …
risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta …
[HTML][HTML] TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human Embryonic Stem Cells towards Endoderm
NAJ Krentz, C Nian, FC Lynn - PloS one, 2014 - journals.plos.org
Human embryonic stem cells (hESCs) have great promise as a source of unlimited transplantable
cells for regenerative medicine. However, current progress on producing the desired …
cells for regenerative medicine. However, current progress on producing the desired …
[HTML][HTML] SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models
EE Xu, NAJ Krentz, S Tan, SZ Chow, M Tang, C Nian… - Diabetologia, 2015 - Springer
Aims/hypothesis The sex-determining region Y (SRY)-related high mobility group (HMG)
box (SOX) family of transcription factors is essential for normal organismal development. …
box (SOX) family of transcription factors is essential for normal organismal development. …
Npas4 is a novel activity–regulated cytoprotective factor in pancreatic β-cells
PV Sabatini, NAJ Krentz, B Zarrouki… - Diabetes, 2013 - Am Diabetes Assoc
Cellular homeostasis requires intrinsic sensing mechanisms to temper function in the face
of prolonged activity. In the pancreatic β-cell, glucose is likely a physiological trigger that …
of prolonged activity. In the pancreatic β-cell, glucose is likely a physiological trigger that …
[HTML][HTML] Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
KK Mattis, NAJ Krentz, C Metzendorf, F Abaitua… - Diabetologia, 2023 - Springer
Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the
RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. …
RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. …