Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis. …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8),
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …

Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …

During pancreatic development, proliferating pancreatic progenitors activate the proendocrine
transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into …

The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered
risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta …

Human embryonic stem cells (hESCs) have great promise as a source of unlimited transplantable
cells for regenerative medicine. However, current progress on producing the desired …

Aims/hypothesis The sex-determining region Y (SRY)-related high mobility group (HMG)
box (SOX) family of transcription factors is essential for normal organismal development. …

Cellular homeostasis requires intrinsic sensing mechanisms to temper function in the face
of prolonged activity. In the pancreatic β-cell, glucose is likely a physiological trigger that …

Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the
RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. …