The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to
adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways …

Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations
of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly …

Understanding the inherited nature of how biological processes dynamically change over
time and exhibit intra- and inter-individual variability, due to the different responses to …

Peroxiredoxins are H 2 O 2 scavenging enzymes that also carry out H 2 O 2 signaling and
chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both …

Background The yeast AMPK/SNF1 pathway is best known for its role in glucose de/repression.
When glucose becomes limited, the Snf1 kinase is activated and phosphorylates the …

Adaptation is an important property of living organisms enabling them to cope with environmental
stress and maintaining homeostasis. Adaptation is mediated by signaling pathways …

Nutrient sensing pathways are playing an important role in cellular response to different energy
levels. In budding yeast, Saccharomyces cerevisiae, the sucrose non-fermenting protein …

Lithium salts are used in the treatment of mood disorders, cancer, and Alzheimer’s disease.
It has been shown to prolong life span in several phyla; however, not yet in budding yeast. In …

Aggregation of misfolded or damaged proteins is often attributed to numerous metabolic and
neurodegenerative disorders. To reveal underlying mechanisms and cellular responses, it …

Methods: We performed a network reconstruction of the Snf1 pathway based on a comprehensive
literature review. The network was formalised in the rxncon language, and we used …