Vitamin D controls T cell antigen receptor signaling and activation of human T cells
Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular
stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and …
stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and …
[HTML][HTML] Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease
…, KW Eriksen, A Woetmann, N Ødum - Journal of Biological …, 2003 - ASBMB
Via cytoplasmic signal transduction pathways, cytokines induce a variety of biological
responses and modulate the outcome of inflammatory diseases and malignancies. Crohn's …
responses and modulate the outcome of inflammatory diseases and malignancies. Crohn's …
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3–dependent expression …
…, L Andresen, P Thor Straten, A Woetmann, N Ødum - Cancer research, 2005 - AACR
We show that histone deacetylase (HDAC) inhibitors lead to functional expression of MHC
class I–related chain A and B (MICA/B) on cancer cells, making them potent targets for natural …
class I–related chain A and B (MICA/B) on cancer cells, making them potent targets for natural …
Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense
…, HM Pike, B Olszak, S Skov, N Ødum… - Genes & …, 2002 - genesdev.cshlp.org
We describe the lethal, recessive accelerated-cell-death11 Arabidopsis mutant (acd11). Cell
death in acd11exhibits characteristics of animal apoptosis monitored by flow cytometry, and …
death in acd11exhibits characteristics of animal apoptosis monitored by flow cytometry, and …
[HTML][HTML] The effect of short-chain fatty acids on human monocyte-derived dendritic cells
The gut microbiota is essential for human health and plays an important role in the
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate and …
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate and …
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor …
…, P Dobson, A Svejgaard, N Ødum - Proceedings of the …, 1997 - National Acad Sciences
Mycosis fungoides (MF) is a low-grade cutaneous T cell lymphoma of unknown etiology. In
this report, the Jak/Stat (Janus kinase/signal transducer and activator of transcription) …
this report, the Jak/Stat (Janus kinase/signal transducer and activator of transcription) …
[HTML][HTML] Cytotoxicity of CD56bright NK Cells towards Autologous Activated CD4+ T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94 …
N Nielsen, N Ødum, B Ursø, LL Lanier, P Spee - PloS one, 2012 - journals.plos.org
In mouse models of chronic inflammatory diseases, Natural Killer (NK) cells can play an
immunoregulatory role by eliminating chronically activated leukocytes. Indirect evidence …
immunoregulatory role by eliminating chronically activated leukocytes. Indirect evidence …
[HTML][HTML] Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter
…, PN Raghunath, E Vonderheid, N Ødum… - The American journal of …, 2000 - Elsevier
SHP-1 is an important negative regulator of signaling by several receptors including
receptors for interleukin-2 (IL-2R) and other cytokines. SHP-1 acts by dephosphorylating the …
receptors for interleukin-2 (IL-2R) and other cytokines. SHP-1 acts by dephosphorylating the …
[HTML][HTML] Vitamin D-binding protein controls T cell responses to vitamin D
…, TB Levring, P Schjerling, A Woetmann, N Ødum… - BMC immunology, 2014 - Springer
Background In vitro studies have shown that the active form of vitamin D 3 , 1a,25-dihydroxyvitamin
D3 (1,25(OH) 2 D 3 ), can regulate differentiation of CD4 + T cells by inhibiting Th1 …
D3 (1,25(OH) 2 D 3 ), can regulate differentiation of CD4 + T cells by inhibiting Th1 …
[HTML][HTML] miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma
…, AG Skov, CM Lerche, BT Lauenborg, N Ødum… - PloS one, 2012 - journals.plos.org
Advanced cutaneous T-cell lymphoma (CTCL) is resistant to chemotherapy and presents a
major area of medical need. In view of the known role of microRNAs (miRNAs) in the …
major area of medical need. In view of the known role of microRNAs (miRNAs) in the …