BCL-2 family proteins: critical checkpoints of apoptotic cell death
NN Danial - Clinical cancer research, 2007 - AACR
Apoptosis is a morphologically distinct form of programmed cell death essential for normal
development and tissue homeostasis. Aberrant regulation of this pathway is linked to multiple …
development and tissue homeostasis. Aberrant regulation of this pathway is linked to multiple …
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
NN Danial, CF Gramm, L Scorrano, CY Zhang… - Nature, 2003 - nature.com
Glycolysis and apoptosis are considered major but independent pathways that are critical
for cell survival 1 , 2 , 3 , 4 . The activity of BAD, a pro-apoptotic BCL-2 family member, is …
for cell survival 1 , 2 , 3 , 4 . The activity of BAD, a pro-apoptotic BCL-2 family member, is …
How does the ketogenic diet work? Four potential mechanisms
NN Danial, AL Hartman… - Journal of child …, 2013 - journals.sagepub.com
The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can
also have antiepileptogenic properties and can eventually have a role in treating other …
also have antiepileptogenic properties and can eventually have a role in treating other …
[HTML][HTML] Cell death: critical control points
NN Danial, SJ Korsmeyer - Cell, 2004 - cell.com
Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans.
An intact death pathway is required for successful embryonic development and the …
An intact death pathway is required for successful embryonic development and the …
UCP1 governs liver extracellular succinate and inflammatory pathogenesis
Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …
[HTML][HTML] OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
…, T Rudka, D Bartoli, RS Polishuck, NN Danial… - Cell, 2006 - cell.com
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and
other cofactors. This is accompanied by fragmentation of the organelle and remodeling of …
other cofactors. This is accompanied by fragmentation of the organelle and remodeling of …
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix
calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP …
calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP …
[PDF][PDF] Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
Molecular signatures have identified several subsets of diffuse large B cell lymphoma (DLBCL)
and rational targets within the B cell receptor (BCR) signaling axis. The OxPhos-DLBCL …
and rational targets within the B cell receptor (BCR) signaling axis. The OxPhos-DLBCL …
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
NN Danial, LD Walensky, CY Zhang, CS Choi… - Nature medicine, 2008 - nature.com
The proapoptotic BCL-2 family member BAD resides in a glucokinase-containing complex
that regulates glucose-driven mitochondrial respiration. Here, we present genetic evidence of …
that regulates glucose-driven mitochondrial respiration. Here, we present genetic evidence of …
[PDF][PDF] Adipsin is an adipokine that improves β cell function in diabetes
A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure,
which results in insulinopenia and hyperglycemia. We show that the adipokine adipsin has …
which results in insulinopenia and hyperglycemia. We show that the adipokine adipsin has …