… R-GECO signal (t 1/2 ) at each granule by fitting a Hill expression F = F max t n /[(t 1/2 ) n + t
n ] to the R… fitted the rise in the simulated, processed R-GECO signal at various distances to a …

Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly
developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic …

Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4
million individuals in 2021. It is primarily classified as an autoimmune disorder, where the …

Recent developments suggest that increased glucagon and decreased somatostatin secretion
from the pancreas contribute to hyperglycaemia in type-2 diabetes (T2D) patients. There …

Docking of secretory vesicles at the plasma membrane is a poorly understood prerequisite
for exocytosis. Current models propose raft-like clusters containing syntaxin as docking …

Circadian clocks operative in pancreatic islets participate in the regulation of insulin secretion
in humans and, if compromised, in the development of type 2 diabetes (T2D) in rodents. …

Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose.
Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through …

Insights into host–virus interactions during SARS-CoV-2 infection are needed to understand
COVID-19 pathogenesis and may help to guide the design of novel antiviral therapeutics. N …

Type 2 diabetes is triggered by reduced insulin production, caused by genetic and environmental
factors such as inflammation originating from the innate immune system. Complement …

10.7554/eLife.41711.001 Regulated exocytosis establishes a narrow fusion pore as initial
aqueous connection to the extracellular space, through which small transmitter molecules …