The widely conserved kinase Aurora B regulates important events during cell division.
Surprisingly, recent work has uncovered a few functions of Aurora-family kinases that do not …

Chromosome congression and segregation in C. elegans oocytes depend on a complex of
conserved proteins that forms a ring around the center of each bivalent during prometaphase…

During mitosis, centrosomes serve as microtubule organizing centers that guide the formation
of a bipolar spindle. However, oocytes of many species lack centrosomes; how meiotic …

Numerous methods have been developed in model systems to deplete or inactivate proteins
to elucidate their functional roles. In Caenorhabditis elegans, a common method for protein …

The nematode Caenorhabditis elegans is a widely used model organism for the study of
mitotic and meiotic cell division. These self-fertilizing worms are particularly advantageous for …

Although end-on microtubule–kinetochore attachments typically drive chromosome alignment,
Caenorhabditis elegans oocytes do not form these connections. Instead, microtubule …

Although centrosomes help organize spindles in most cell types, oocytes of most species
lack these structures. During acentrosomal spindle assembly in C. elegans oocytes, …

Although end-on microtubule–kinetochore attachments typically drive chromosome alignment,
Caenorhabditis elegans oocytes do not form these connections. Instead, microtubule …

… elegans Oocytes Nikita S. Divekar In eukaryotes, sexual reproduction is dependent on a
specialized type of cell division known as meiosis. Meiosis gives rise to haploid gametes, such …

This painting summarizes the concepts underlying this work. The blood vessel in the center
of the painting contains a thrombus, the phenotypic target for our screen. The left side of the …