The loss of regenerative capacity is the most dramatic age-associated alteration in the liver.
Although this phenomenon was reported over 50 years ago, the molecular basis for the loss …

HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and
-8. Although HDAC1 has been mostly studied in the context of cancer, recent evidence …

The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is a strong inhibitor of
cell proliferation. We found that C/EBPα directly interacts with cdk2 and cdk4 and arrests cell …

C/EBPalpha has a role in growth arrest and differentiation of mouse preadipocytes. To study
the mechanism of C/EBPalpha-induced growth arrest, we developed a cell line, HT1, that …

Patients with alcoholic liver disease frequently exhibit iron overload in association with
increased hepatic fibrosis. Even moderate alcohol consumption elevates body iron stores; …

An RNA CUG triplet repeat binding protein, CUGBP1, regulates splicing and translation of
various RNAs. Expansion of RNA CUG repeats in the 3′-untranslated repeat of the mutant …

Liver cancer is the fifth most common cancer and the third most common cause of cancer
related death in the world. The recent development of new techniques for the investigations of …

The liver is capable of completely regenerating itself in response to injury and after partial
hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the …

CCAAT/enhancer binding protein α (C/EBPα) is expressed at high levels in quiescent
hepatocytes and in differentiated adipocytes. In cultured cells, C/EBPα inhibits cell proliferation in …

Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the
induction of a CUG-binding protein, CUGBP1, which increases translation of several …