Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

… Nikolaos A Patsopoulos, research associate, … John Ioannidis, Nikolaos Patsopoulos,
and Evangelos Evangelou argue that, although meta-analyses often measure …

Background Several approaches are available for evaluating heterogeneity in meta-analysis.
Sensitivity analyses are often used, but these are often implemented in various non-…

Clinical trials have been the main tool used by the health sciences community to test and
evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory. …

ContextThe relative merits of various study designs and their placement in hierarchies of
evidence are often discussed. However, there is limited knowledge about the relative citation …

To extend our understanding of the genetic basis of human immune function and dysfunction,
we performed an expression quantitative trait locus (eQTL) study of purified CD4 + T cells …

… John Ioannidis, Nikolaos Patsopoulos, and Hannah Rothstein show that final synthesis is
possible and desirable in most cases … Ioannidis JP, Patsopoulos NA, Evangelou E …

Background Meta-analysis is the systematic and quantitative synthesis of effect sizes and
the exploration of their diversity across different studies. Meta-analyses are increasingly …

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis
(MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles …