The cellular processes underpinning life are orchestrated by proteins and their interactions.
The associated structural and dynamic heterogeneity, despite being key to function, poses a …

Protein assembly is a main route to generating complexity in living systems. Revealing the
relevant molecular details is challenging because of the intrinsic heterogeneity of species …

In spite of their great importance in biology, methods providing access to spontaneous molecular
interactions with and on biological membranes have been sparse. The recent advent of …

Tropomyosin isoforms play an important role in the organisation of cytoplasmic actomyosin
complexes in regard to function and cellular localisation. In particular, Tpm4.2 is upregulated …

The metazoan actin cytoskeleton supports a wide range of contractile and transport processes.
Recent studies have shown how the dynamic association with specific tropomyosin …

Cytoplasmic β‐actin supports fundamental cellular processes in healthy and diseased cells
including cell adhesion, migration, cytokinesis and maintenance of cell polarity. Mutations in …

Single-molecule imaging has mostly been restricted to the use of fluorescence labelling as a
contrast mechanism due to its superior ability to visualise molecules of interest on top of an …

In Gram-positive bacteria, the McsB protein arginine kinase is central to protein quality
control, labeling aberrant molecules for degradation by the ClpCP protease. Despite its …

The plasma membrane and the underlying cytoskeletal cortex constitute active platforms for
a variety of cellular processes. Recent work has shown that the remodeling acto-myosin …

The cellular processes underpinning life are orchestrated by proteins and their interactions.
Structural and dynamic heterogeneity, despite being key to protein and drug function, …