A highly multiplexed cytometric imaging approach, termed co-detection by indexing (CODEX),
is used here to create multiplexed datasets of normal and lupus (MRL/lpr) murine spleens. …

INTRODUCTION Single-cell RNA sequencing has demonstrated that both stable cell types
and transient cell states can be discovered and defined by transcriptomes. In situ …

Advances in multiplexed imaging technologies have drastically improved our ability to
characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing (…

Antitumoral immunity requires organized, spatially nuanced interactions between components
of the immune tumor microenvironment (iTME). Understanding this coordinated behavior …

Endocytosis is a complex process fulfilling many cellular and developmental functions.
Understanding how it is regulated and integrated with other cellular processes requires a …

Accurate identification of cell subsets in complex populations is key to discovering novelty in
multidimensional single-cell experiments. We present X-shift ( http://web.stanford.edu/~…

The expansion of the neocortex during mammalian brain evolution results primarily from an
increase in neural progenitor cell divisions in its two principal germinal zones during …

Neuroinflammation and neurodegeneration may represent two poles of brain pathology.
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …

Advances in multiplexed in situ imaging are revealing important insights in spatial biology.
However, cell type identification remains a major challenge in imaging analysis, with most …

Muscle regeneration is a dynamic process during which cell state and identity change over
time. A major roadblock has been a lack of tools to resolve a myogenic progression in vivo. …