Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum
disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia …

Stimulation of neutrophil reverse migration presents an attractive, alternative therapeutic
pathway to driving inflammation resolution. However, little is known about whether the activity of …

Interleukin-1 (IL-1), the ‘gatekeeper’ of inflammation, is the apical cytokine in a signalling
cascade that drives the early response to injury or infection. Expression, processing and …

Drug-resistant mycobacteria are a rising problem worldwide. There is an urgent need to
understand the immune response to tuberculosis to identify host targets that, if targeted …

Infection by rapidly growing Mycobacterium abscessus is increasingly prevalent in cystic
fibrosis (CF), a genetic disease caused by a defective CF transmembrane conductance …

The neutrophil enzyme myeloperoxidase (MPO) is a major enzyme made by neutrophils to
generate antimicrobial and immunomodulatory compounds, notably hypochlorous acid (HOCl…

Many key components of innate immunity to infection are shared between Drosophila and
humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. …

The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular
survival. Defects in neutrophil number and survival are common to both hematologic disorders …

Inflammatory diseases are a significant burden on global healthcare systems, and tackling
these diseases is a major focus of modern medicine. Key to many inflammatory diseases is …