Accumulation of human CD21 low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders. The …

Background: Some nucleoside analogue reverse transcriptase inhibitors (NRTI) may cause
depletion of mitochondrial (mt) DNA in liver by inhibiting polymerase-γ. mtDNA depletion …

Objective To assess the impact of immunosuppressive therapy with cyclophosphamide (CYC)
and rituximab (RTX) on serum immunoglobulin (Ig) concentrations and B lymphocyte …

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct
transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of …

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare anti-neutrophil cytoplasmic
antibody (ANCA)-associated vasculitis, characterized by asthma, eosinophilia and …

Background Some nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) combinations
cause additive or synergistic interactions in vitro and in vivo. Methods We evaluated the …

Objectives: Tenofovir disoproxil fumarate (tenofovir DF) use has been associated with renal
dysfunction and Fanconi syndrome. Tenofovir is taken up into renal tubules by anion …

The central role played by cerebrospinal-fluid (CSF) examinations including antineuronal
autoantibody (Ab) testing is increasingly recognized in psychiatry. The rationale of this study …

Objective To describe the efficacy and safety of biologics for the treatment of eosinophilic
granulomatosis with polyangiitis (EGPA). Methods A retrospective European collaborative …

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V , that alters the two-…