Sigma-1 receptors (σ-1Rs) are endoplasmic reticulum resident chaperone proteins implicated
in many physiological and pathological processes in the CNS. A striking feature of σ-1Rs …

Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new
genetic drug modalities. However, their high molecular weight limits their bioavailability for …

Wound healing is a complicated biological process that consist of partially overlapping
inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends …

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA)
signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-…

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of
approved treatments for this devastating condition has significantly changed SMA patients' …

Adenovirus type 37 is one of the main causative agents of epidemic keratoconjunctivitis. In a
series of publications, we have reported that this virus uses sialic acid as a cellular receptor. …

Therapies that restore dystrophin expression are presumed to correct Duchenne muscular
dystrophy (DMD), with antisense-mediated exon skipping being the leading approach. Here …

Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event,
neuronal death is triggered by uncontrolled glutamate release leading to overactivation of …

The sigma-1 receptor (σ-1R) is an endoplasmic reticulum resident chaperone protein involved
in a plethora of cellular functions, and whose disruption has been implicated in a wide …

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor
neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. …